Genetic Engineering of Bacteria that can Produce Urate Oxidase

Because the human body cannot synthesize urate oxidase by itself, reducing the level of uric acid requires long-term or even lifelong treatment. However, currently various uric acid-lowering drugs cause different degrees of damage to the human body and thus are not suitable for long-term treatment. A probiotic that can yield a large amount of urate oxidase and be transplanted into the intestines to constantly produce urate oxidase to catalyze uric acid would have important economic and ecological value. Thus, we cloned the urate oxidase gene into Lactobacillus bulgaria to assess urate oxidase production and activity as an alternative drug therapy for hyperuricemia.